Supreme Pharmacist System Chapter 292: Analgesics that do not produce euphoria

"It is said that Huanyu has completed the development of the active compound and is currently undergoing pharmacological evaluation."

Lang Yongfeng, executive director of Tianfeng Zhengda, said looking at the paper data on the table.

As a pharmaceutical company started with generic drugs, Tianfeng Zhengda has also invested a lot of money in new drug research in the past two years.

However, the development of new drugs does not yield results in a short period of time, and it does not mean that results are guaranteed.

Even if it reaches the clinical trial stage, as the evaluation of drugs becomes more and more difficult, fewer and fewer new drugs can be marketed through all Phase 3 clinical evaluations.

Part of the reason is that it is getting harder and harder to develop new drugs with better comprehensive evaluations than existing drugs on the market. For example, the FDA (US Food and Drug Administration) approved only 35 new drugs last year.

For example, a new class II drug that Tianfeng Zhengda invested heavily in research and development before has entered the second phase of clinical trials, but it died prematurely. The initial investment of 75 million US dollars was completely lost.

Of course, drug R&D is also an industry with high investment, high risk and high return.

Once the drug is on the market, the payoff can be staggering.

There is a term in the industry called "blockbuster", which refers to drugs with annual sales of more than $1 billion.

An extreme example is Pfizer's patent-protected lipid-lowering drug Lipitor, which in 2010 achieved a staggering $10.133 billion in global sales.

Hearing Lang Yongfeng's words, a middle-aged man with four eyes pushed the frame on the bridge of his nose and said: "This company's research and development capabilities are very strong, and it is almost a certainty that it has entered the clinical trial stage; What's the success rate?"

Another man with three beards, smoking a cigarette, said, "I think you are all unfounded. Where is this going? Even clinical trials have not started. What is there to worry about."

Lang Yongfeng shook his head and said, "You're wrong, I'm not worrying about nothing. He Junfeng, the chief scientist of Type B of the Academy of Sciences, has joined their team. Do you know what this means?

You may not know He Junfeng. He is very arrogant. At the beginning, Mr. Xie wanted to invite him to be our company's chief expert consultant, and he even offered tens of millions of annual salary + reward equity. refused.

The fact that he can join the universe creature only means that the other party must have something that he cannot refuse. "

The four-eyed middle-aged man said, "Mr. Lang means... Universal Bio has made a breakthrough discovery in the treatment of hepatitis B?"

Lang Yongfeng nodded affirmatively: "Yes!"

…

Kapok City, Sichuan Province, Ruiyang Pharmaceutical Factory, Science and Technology Park Avenue.

Ruiyang is only a small pharmaceutical factory, mainly engaged in the manufacture of pharmaceutical preparations. There are only more than 30 employees in total, and there are also four technicians.

These technicians, in addition to being responsible for the daily production in the factory, also conduct some drug research.

Primarily pain relievers.

The reason why they researched painkillers was mainly because of Fu Le, the owner and technical director.

Fu Le used to be an anesthesiologist. He quit his job seven years ago because of some things, and accidentally entered the pharmaceutical industry. Then, in his spare time, out of personal hobbies, he began to study painkillers.

But today, Ruiyang Pharmaceutical Factory is about to close down. Because of the shrinking OEM business, the factory can no longer support it and has to close its doors.

At this time, the four technicians in the laboratory looked at the packed experimental equipment on the ground with expressions of reluctance, but it was useless to resign, they still had to live and had to find another way to make a living.

It's just a pity that the boss, Fu Le, is a man with ideals and sentiments, and he has given practical actions to his dreams.

"Let's go and say goodbye to the old man."

"Go..."

Several people looked at the experimental instruments on the ground again, and left the laboratory with a sigh.

In the office, a man in his forties with a thin face is calculating the company's property according to the documents given by the accountant.

After some calculations, after deducting various expenses, not only did not have a penny left after selling all the equipment, but also owed hundreds of thousands of dollars.

This man is naturally Fu Le, the owner of Ruiyang Pharmaceutical Factory.

Fu Le gave a wry smile. In May 2013, it has been 7 years since today, and in the end, he still has nothing and accomplishes nothing.

Fortunately, his wife divorced him a long time ago and took the child with him, otherwise he would not even have a place to stand now.

"Good!"

Fu Le picked up the phone and called the used equipment recycler, "Hey Boss Zhang, come and pull the equipment..."

After the call, Fu Le closed the computer and planned to leave, but at this moment, the desk phone rang.

"Hello, who are you?"

A very contagious baritone voice came from the other end of the phone, "Are you Mr. Fu?"

Fu Le: "Yes, I am, who are you?"

Baritone: "I'm Tong Miao, an evaluator of the Universal Biological Research Foundation. After we received your application, we have evaluated your company and experimental projects. Now I have some questions to ask you. Is it convenient?"

"Universal Foundation?" After listening to the other party's words, Fu Le was stunned for a moment, and then suddenly remembered that he seemed to have filled out an application form last month.

"By the way, the Universal Research Grant."

Fu Le suddenly remembered.

In the middle of last month, he applied for a research grant of RMB 1 million from the Universal Research Foundation.

Although I knew there was little hope, I was desperate at the time, so I filled in some information in the hope of contingency.

I didn't expect the Foundation to call me.

"Well, you asked." Unconsciously, Fu Le's words became more respectful.

No way, who made the other party the God of Wealth? Whether Ruiyang can continue to maintain it depends on whether the other party will let go.

Tong Miao: "The whole call was recorded."

Fu Le: "Yeah! Got it."

Tong Miao: "Okay, let's start now. I read the application description that you have been an anesthesiologist for 11 years, why didn't you do it in the end?"

Fu Le: "Because of emotional problems."

Tong Miao: "Then why did you think of researching painkillers again?"

Fu Le: "Because I believe that any real anesthesiologist would like to develop an analgesic that can effectively block pain without producing euphoria."

Tong Miao: "I don't quite understand, can you explain the reason in detail?"

Fu Le: "Okay! It sounds a bit nonsensical. Analgesics are a part of the pain relief. Wouldn't it be better to provide euphoria and relief?

However, countless problems in the world lie in this "make you cool" feeling.

The word euphoria sounds high-sounding, but it is almost two-in-one with the words "D inhalation", "D addiction", and "withdrawal reaction".

You may not know, a sad fact is that the analgesics that save hundreds of millions of cancer and severe pain patients, and are necessary for surgery, are being abused by drug addicts who pursue pleasure, and become a topic of conversation. "Product D".

You think that the most commonly used analgesics are opioids. The opioid here is actually a euphemistic English translation. In fact, the accurate name is Y tablets.

Opioids originally referred to resin exudates extracted from poppy capsules. Later, with the development of the chemical industry, they transitioned to artificial semi-synthetic and fully synthetic anesthetic and analgesic drugs.

Morphine, buprenorphine, fentanyl, domeridine, tramadol, methadone, etc. are commonly used in clinical practice, as well as various types of pain reliever patches and lotions also contain opioids.

As a strong analgesic, opioids enter the nervous system and combine with opioid receptors, which can rapidly increase the body's pain threshold, reduce the body's perception of pain, and produce a strong analgesic effect.

But its other function is to give users a special euphoria and a very pleasant and comfortable feeling, which is the root cause of the abuse of such drugs.

Euphoria and Addiction are almost inseparable ~IndoMTL.com~ Extraordinary pleasure is both pleasure and hell.

Being cool is not a problem, the problem is to be cool all the time.

The human desire to seek intense stimulation is almost endless.

After experiencing a thrill far beyond imagination, any ordinary stimulus is like tickling. Once the pleasure threshold is raised, it is difficult to suppress.

The so-called transition from extravagance to frugality is difficult, and it is an addiction.

An addictive word has ruined countless people.

As an anesthesiologist, I am saddened to see that many drugs that were originally invented to benefit human beings have been abused as D-products, which not only stigmatizes the drug, but also provides legitimate analgesia for extreme pain. Serious crimes committed by patients in need.

For example, chloramine-tong is an excellent short-acting analgesic in the field of pediatric anesthesia. It has fast onset, fast metabolism, and has the function of dissociative anesthesia. It is very suitable for use in pediatric short-term surgery.

But it's now called K-Powder, and no one knew it used to be a good helper for the anesthesiologist.

Because of this, I especially hope to understand the entire pain signal as soon as possible, and develop an analgesic that can effectively block pain without relying on opioid receptors..."

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