Technological Supremacy Chapter 514: The mystery of aging, MTOR gene signaling pathway!
Luo Jia picked up the ink pen that had been prepared and wrote on the whiteboard in the meeting room, writing down many complicated and mysterious codes. The Wen brothers took a glance and knew that they were genetic codes.
On the other side, Wen Chengfeng cleared his throat, and began to summarize the recent work of the Life Science Department. Luo Jia showed great trust in them, and never urged the progress of the research, and even did not come to inspect once a few months. But since Luo Jia has come this time, it is human nature to always report to the boss.
"In the past six months, the biggest research achievement of the Department of Life Sciences has been to clarify some issues related to human lifespan. First, can human beings live longer?"
Wen Chengfeng glanced at Luo Jia, "The answer is yes, of course it is possible for human beings to obtain a super long lifespan, because as we all know, our body cells are undergoing metabolism all the time."
"Take the superficial skin that women are most concerned about. It takes a total of 14 days for keratinocytes to die. Eleven to forty-seven days."
"According to different ages, the speed of metabolism will also vary. Young people have a short metabolic cycle, while older people have a longer metabolic cycle."
"That is to say, it only takes forty-seven days at most, and our face is no longer the face of the past, but a new face through cell metabolism."
"Of course, cell-level metabolism is a change at the micro level. From the outside, it seems that everything remains the same, but the cells that make up the epidermis of the face have changed to a new batch compared with forty-seven days ago. An indisputable fact."
Luo Jia nodded slightly. Human beings are made up of cells, and cell renewal is going on all the time. From the perspective of cells, the you of yesterday and the you of today are actually different.
Wen Chengfeng continued: "The lifespan of liver cells is only five months, and then they will die and replace. Even our bones will complete a round of cell replacement every ten years. After middle age, the bone renewal speed Slow down, so osteoporosis is formed, so the elderly are prone to fractures after falling, the root cause is not that the bones become weaker, but the metabolism of our elderly slows down." New 81 Chinese website updates the fastest computer terminal: https://
"It can be seen that if we can control the speed of metabolism, it is equivalent to unlocking the code of longevity, and human metabolism is controlled by genes. What we are doing is to find and control the set of genes related to lifespan .”
"Currently, the only way we have confirmed the correct way to open up longevity is called energy restriction. Simply put, it means eating less and being seven percent full every time you eat."
"We tested it on humans, we tested it on mice, we tested it on cells, we tested it on almost all species, by controlling diet and reducing calorie intake, we finally achieved success..."
Wen Chengfeng introduced a lot to Luo Jia, from the past to the present. Brother Wen, it was an extremely correct decision.
Science is not child's play, and requires strict, quantifiable standards.
Luo Jia forgot to read it in an online novel. There is a technology mentioned in the novel, life extension technology. How about a life extension method? Anyway, it makes people look young.
Looks very young...
Hey, Luo Jia is really powerless to complain about this kind of idealistic subjective description.
As for the set of standards formulated by the Wen brothers, the specific items include the following items:
1 Glycoprotein.
2 Breathe hard in one second.
3 arterial blood pressure.
4 total cholesterol.
5 reactive protein.
6 creatinine clearance.
7 urea nitrogen.
8 Cardiorespiratory fitness.
9 waist-to-hip ratio.
10 Max vital capacity ratio.
11 body mass index.
12 Leukocyte telomere length.
13 lipoproteins.
14 Triglycerides.
15 Periodontitis.
16 white blood cell count,.
17 HDL.
18 apolipoprotein ratio.
This is the correct attitude towards science. In order to study anti-aging, they first used 18 rigorous data to define what aging is. Along with this standard, there is also a set of algorithms and mathematical models that will The current aging coefficient can be obtained by inputting personal indicators.
"This is the current research status of the Department of Life Sciences." Wen Chengfeng concluded: "We have done a lot of research, defined the standard of aging, and found some organ-level metabolic control technologies, such as our superficial skin metabolism. Management has achieved quite good results. The company's cosmetics department swept the world, and obtained an astonishing amount of wealth from beauty-loving female consumers, and these wealth eventually became a space elevator and research funding for our department. "
"To be honest, I was a little shocked. In order to smooth out the crow's feet around the eyes, women are willing to pay such a high price? This is unscientific! Isn't it just a few wrinkles, why are they so aggressive?"
Hearing Wen Chengfeng's complaints, Luo Jia almost laughed out loud. The atmosphere of straight men in the company is too serious. The brothers of the Wen family are all in their forties. They are not young, but they are still honest and messy .
Unscientific?
When did a creature like a woman become scientific?
Luo Jia coughed twice, stood up, and came to the whiteboard, "I have already understood the specific situation, and the Life Science Department is doing a good job. In short, I can rest assured of you one hundred and twenty."
"Next, I want to talk about my discovery in my spare time. Since the advent of distributed supercomputing and artificial intelligence, the threshold for scientific research has been greatly reduced. Not only can I build models by myself, do genetic deduction, and even Junior high school students and elementary school students who have an understanding of genetic science can also engage in research they are interested in, and simulate the evolution of genes and the path of their effectiveness on supercomputers.”
Huaxia's distributed supercomputing system is now becoming more and more powerful. The whole country is connected to the Internet, and its computing power has risen crazily. It has reached the point where it is open to all individual users. Research.
Of course, there is still a big gap between the ideal and the reality. According to the statistics of the Supercomputing Administration, the largest application of the Huaxia Distributed Supercomputing System is game computing, and the second largest application is CG rendering.
That is to say, everyone didn't do academics, but used supercomputing resources to develop games, and do post-rendering for movies and animations, so that the pictures of small movies are clearer and more moving, and the sound is more numb and trembling.
Luo Jia is not against games. He played games a lot back then. The key is that games need to be graded and restricted. As long as young people are not addicted to them, they can play games for two hours a day. Luo Jia has no objections.
As for the small movie becoming clearer, Luo Jia didn't say anything, but secretly gave her a thumbs-up in her heart. High-definition small movie combined with panoramic VR is a good thing. Whoever sees it will know.
Luo Jia explained to the Wen family brothers that he was engaged in life science research in his spare time, and you don't have to doubt any scary conclusions he came up with later. Luo Jia has always been careful about covering up the truth about the Golden Dome.
Luo Jia pointed to a line of words he wrote on the whiteboard earlier and said: "mammaliantargetofrapamycin, mammalian target of rapamycin, referred to as MTOR."
"MTOR is a kind of threonine kinase. The C-terminal is homologous to phosphatidylinositol kinase, but it does not have the activity of esterase kinase, but protein kinase activity. I deduced MTOR through supercomputing , and found some very strange phenomena, it seems that the MTOR gene signaling pathway has the function of controlling substance metabolism and cell autophagy." New 81 Chinese website updates the fastest mobile terminal: https://
After hearing Luo Jia's opening, the Wen family brothers were taken aback by the explanation and cheered up.
"Impossible! Could it be that Mr. Luo found a gene pathway that controls metabolism and autophagy!?"
The Wen brothers screamed in their hearts. They were all shocked. The gene signaling pathway is actually not a new thing. It was discovered by scientists as early as 1972.
To put it simply, protein kinases and phosphatases are used as signal transmission substances to finally give orders to cells, telling cells that you should divide and proliferate, and that you are already aging, so don't just stand in the latrine and don't shit, hurry up and judge yourself ball and so on.
You can order the child to wash his hands before eating, but you cannot order the child to grow taller quickly, at least to grow to 1.8 meters, and to have charming small eyes and long legs like Korean Obama.
However, the gene signaling pathway can do it, because it can directly issue orders to cells. Tens of billions of cells are the most basic unit of the human body. Changes in cells will eventually lead to global changes.
Since the gene signaling pathway is so powerful, why don't we try to write human genes, prevent aging, and let everyone grow long legs?
The reason is very simple, it is too difficult.
The human genetic map consists of 25,000 genes and 3 billion bases, which is too large.
However, if you think that this is all human genes, you can only say that you are still too naive.
In addition to the above, there are over a million bacterial genes in the human body, because the human body contains about a hundred trillion cells of other organisms.
That is to say, 90% of the cells in our body do not belong to us. Our body is actually composed of bacterial flora and some human cells attached to it.
During the evolution of hundreds of millions of years, our body cells and trillions of microorganisms coexisted and coexisted. Microbes have affected the evolution of every organ of ours, including the brain and heart. The DNA of microorganisms has already penetrated into the human body. In the DNA, the DNA of microorganisms has already become an integral part of human DNA!
It has been said that human beings are the most complex beings in nature, and from a genetic point of view, this statement is true.
Human genes are really complicated. It is almost impossible to find a path to completely control aging in such a complex gene sequence~IndoMTL.com~, even developed extraterrestrial civilizations cannot do it.
The MTOR pathway provided by Lan Yu to Luo Jia is not a complete life control, but to a certain extent, control metabolism and cell autophagy. The 2016 Nobel Prize in Biology and Medicine was awarded to cell autophagy. The discoverer of the principle of phagocytosis, it can be seen that the research of the earth's people in the field of genes is just in its infancy.
However, today, Luo Jia came to the Wen brothers' laboratory and brought them a gene signaling pathway that can control metabolism and autophagy, which made the Wen brothers tremble with excitement!
They couldn't believe what kind of **** luck it was that Luo Jia accidentally discovered a gene signaling pathway that was probably controlled by aging while doing genetic calculations in his spare time! ?
After the introduction, the Wen brothers were dumbfounded. Luo Jia put down the ink pen lightly and shrugged, "I am a layman in the field of life sciences, but according to the results of the supercomputing model, the MTOR Gene signaling pathways may ultimately control the speed of cell metabolism and trigger autophagy.”
"I was thinking, if we renew all the aging cells in the body through the principle of autophagy, wouldn't it be equivalent to washing the marrow in the I Ching in martial arts novels and reborn? It seems very tricky, how about you According to this gene pathway, let's experiment a little bit?"
After hearing Luo Jia's words, the Wen brothers stared wide-eyed.
Have a head?
If Luo Jia's model deduction is correct, the MTOR signaling pathway is more than a mess, it is going to be a big deal!