Supreme Pharmacist System Chapter 154: Let there be no difficult medicine in the world
After the greeting, Zheng Lina said half-jokingly and half-seriously, and proposed to work here with Zhou Wen.
Zhou Wen had a little surprise.
He was about to recruit another employee, but he didn't expect it to come.
Originally, it was enough to have Tang Xin as an assistant, but he has been busy recently, and he has no time to extract high-concentration DNA.
So he planned to train a successor to help him make high-concentration DNA.
Tang Xin is naturally the best choice. He knows the basics and has a relatively calm personality, which is very suitable.
Zhou Wen happily agreed to Zheng Lina's request to stay.
"As for the specific work content, I will let Tang Xin teach you later."
Zheng Lina was naturally overjoyed and nodded again and again, "Hmmmm, I know~ Thank you."
Zhou Wen then said to Tang Xin, "I will teach you to extract DNA today."
"Ah... I'm afraid I won't be able to learn."
Tang Xin was a little surprised to hear that. Although she has dissected mice in college, she mainly did pharmacological experiments and did not extract DNA.
"Oh, very simple, not as complicated as you think."
Just do what you say, Zhou Wen immediately started on-site teaching.
He took a mouse out of the cage, came to the operating table and said, "The first thing is to kill the mouse. This is a little different from what you did for the pharmacological test. We mainly take the bone marrow of the femur of the mouse..."
How did Zhou Wen's professor Tang Xin extract more mouse bone marrow?
He taught very slowly and meticulously. These experiences were obtained from theory and practice after he obtained the system. It is simpler and easier to understand than any professor in the world.
Tang Xin can basically understand it once.
Of course, the extraction of DNA does not rely on theoretical experience, without it, only familiarity.
So after Tang Xin understood the principle, Zhou Wen directly gave up the console and let her get started, while he corrected the technique on the spot.
Including the centrifugation time, the method of extracting the supernatant, the number of pipetting, the amount of fixative added, etc., all carefully taught.
And even Qin Haitao didn't get this kind of hands-on teaching treatment...
For the next period of time, Zhou Wen basically spent his time in the Institute of Medicine.
While teaching Tang Xin the method of DNA extraction, he was doing pharmaceutical tasks by the way.
In addition, he pumped the air conditioner to dispense some optimal proportions of low-permeate fluid.
The key is to ensure that the highest concentration of DNA can be extracted every time, otherwise it can only extract DNA with a slightly higher concentration than ordinary DNA.
A week later, Tang Xin was able to complete the DNA extraction independently. Although the concentration is not high.
But it's also an amazing thing.
Tang Xin was overjoyed when she observed the mouse DNA in the electron microscope.
"Wow~ that's great..."
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Saturday, December 29, the day before New Year's Day.
Jiangzhou First People's Hospital Prion Research Institute was officially established.
This is also the second prion research institute in China, and its scientific research strength is recognized as the first in China.
The first director of the institute was Li Wenshuo.
Li Wenshuo, whose daughter-in-law has become a mother-in-law for many years, had tears in her eyes at the unveiling ceremony.
He has been studying prions since the second year of research, and it has been eight years now, and nothing has been accomplished.
At the worst time, because I could not apply for scientific research funding, I had to go to a joint with a few colleagues to set up a street stall.
Now that I think about it, it is also a bitter tear.
Because of this, Li Wenshuo is very grateful to Zhou Wen. At the darkest moment of his life, he pulled him a hand and arranged a chair for him on the rocket in the sky. The little guy suddenly became a world-renowned prion expert!
After taking a group photo with some leaders and scholars who came to attend the unveiling ceremony, Li Wenshuo invited several fellow scholars from afar from home and abroad to discuss in detail in the office.
As soon as everyone entered the office, they found a large photo of a person hanging on the wall.
"Hey, this person looks familiar."
Li Wenshuo looked at the picture of Zhou Wen on the wall and smiled: "Yes, he is the inventor of PsC1, Zhou Wen, my idol."
Li Wenshuo is not only grateful to Zhou Wen now, he even admires this young man who is nearly 10 years younger than him. That's why he got a photo of Zhou Wen and hung it in his office, just like chasing stars.
Professor Qin Ziyu, deputy director of the China Institute of Prion Research, said unfortunately: "He clearly has an outstanding talent in prions, I don't know why he doesn't continue to study it further?"
Li Wenshuo smiled: "I have asked him about this issue.
He said that there are too many diseases in this world, and various viruses and bacteria are threatening human life and health, which often makes him feel powerless.
That's why he gave up research on prions, and instead engaged in more advanced genetic research, hoping that one day he could crack the human genetic code and cure more diseases. "
Qin Ziyu sighed after hearing the words: "Although I don't agree with him doing this, but no matter what, his courage is commendable."
Li Wenshuo nodded, followed with a smile: "This morning, the US MIT..."
No. 2333, Jiangzhou Science and Technology Park, Institute of Cryptococcosis Novel.
The site renovation here, as well as equipment personnel, etc., are all in place.
The fifteen newly recruited PhDs in cell engineering also have a preliminary understanding of the projects to be studied next.
And the result of understanding is that everyone is dumbfounded.
On the basis of their level, it is impossible to clone antigen serum cells;
Not to mention that the content of antigenic B cells in serum is as low as a terrible number, even if B cells are isolated, the sensitivity and specificity of their sequence amplification and determination are very high.
Even if the sequence is finally amplified and the antibody is expressed, the final effect of the antibody is still open to question.
If they really have this level, how can they be reduced to not being able to find a job, they have already gone to Europe and the United States to earn money.
At noon, Henry Zhang, the head of the research group, found Qin Haitao and asked, "Do you know what Zhou Suo's plan is? Now the work is completely impossible to start, and even has no direction at all."
Qin Haitao said with a smile: "Don't be impatient~ You guys first have a good understanding of Cryptococcus and the composition of the antibacterial serum. As for how to develop it, this will be explained in more detail when the Zhou Institute comes."
Henry Zhang said helplessly: "Okay..."
Jinhu District Industrial Park, No. 404, Huanyu Institute of Biotechnology.
Unlike Henry Zhang and the others, doctoral students like Wang Wei have had a very fulfilling time.
According to the company's requirements, they have a detailed understanding of mainstream biotechnology at home and abroad, such as molecular biology, transgenics, bacterial communities, natural products and plant synthetic biology, clinical bioprocessing, etc.
91 people, three in a small group and thirty in a large group, learn from each other, communicate with each other, compete with each other, and initially build a good and orderly academic ecological environment.
Such an ecological academic environment is the dream of all biological students in China.
However, building such an academic environment requires very high funding.
In the past week, 210,000 yuan has been spent, with an average of about 3,000 yuan per person.
You must know that this is only the most basic scientific research guarantee. If you go back and wait for the opening of the laboratory, if you all go to the laboratory, the cost will be increased by at least 5 times.
1 million a week.
A month is 4 million.
Don't mention anything in a year, at least 50 million in research funding.
This is also the reason why Zhou Wen hesitated before.
The task seems to be simple, but in fact the real difficulty lies in the business development behind.
If the product cannot be developed as soon as possible, the institute will close down soon.
At two o'clock in the afternoon, in the office of Hengfeng Building, Chen Zhiyuan looked at the thick stack of bills on the desk with a pained expression on his face.
During this time, spending money such as running water, office space, office consumables, equipment and equipment, activity funds, etc., etc., every day when you open your eyes is money.
I don't know Chai Migui when he's not at home. It's the first time he knows that the boss is under such a lot of pressure.
The first 50 million funds have been fully received, but more than 3 million have been spent.
This is "little money".
The real big boss is equipment purchases, and the bill on the table is the equipment list.
A total of 36 million! 2 million advance has been paid.
The total price of 10 sets of Hitachi High-tech S-3700N, Hitachi High-tech S-4800, Hitachi High-tech SU-70, etc. of different types of electron microscopes exceeds 20 million RMB.
It's so scary!
After Chen Zhiyuan carefully checked the bill, he went to the financial room and asked them to make the final payment to the supplier.
Just came out of the finance room when the phone in my pocket rang.
When I took it out, it was an unfamiliar local number.
Chen Zhiyuan said after connecting: "Hello, I'm Chen Zhiyuan, who are you?"
"Hello Mr. Chen, I'm Meng Xiang, general manager of Jiangzhou Tianhai Intellectual Property Agency Co., Ltd. Mr. Zhou's patent application has been approved. He will ask you to come and take over some procedures."
Chen Zhiyuan asked curiously: "What kind of patent?"
Meng Xiang: "The production process of sildenafil granules."
"What, sildenafil?" Chen Zhiyuan exclaimed.
Meng Xiang: "Yes! If you have time now, you might as well come to the company."
Chen Zhiyuan hurriedly said: "Okay, I'll go there now, where is the address..."
Hanging up the phone, Chen Zhiyuan was so excited that he almost jumped up.
He had eaten that powerful sildenafil pellet, and the effect was amazing. If it was produced later, hehehe...
And Zhou Wen said that this medicine will be represented by the world.
Thinking of this, Chen Zhiyuan immediately set off for Tianhai Company.
After he arrived at the company, Zhou Wen followed.
After Meng Xiang's remarks, the two excited hearts were instantly chilled as if a basin of cold water had been poured.
According to the Food and Drug Administration, the new sildenafil granules already belong to the category of new drugs. If you want to produce and sell them, you need to go through the clinical trial process again.
Zhou Wen's dream of collecting royalties was shattered.
According to the normal clinical trial process, it takes at least 3 years from human trials to marketing.
Chen Zhiyuan was speechless: "Does it take so long?"
Meng Xiang nodded and said: "Yes! The normal process is like this~IndoMTL.com~ Zhou Wen asked: "What about the abnormal process? "
Meng Xiang said with a smile: "There is another way, the green channel of rapid review. If it works, the clinical trial can be completed in about 12 months.
Because after all, sildenafil is also a drug that has been tested in the market for many years. On the basis of the same raw materials and formula, the production process has only been improved, and there should be room for operation.
You can talk to the CRO company about this, they should have a solution. "
Hearing Meng Xiang's words, Zhou Wen's eyes suddenly lit up, "Yeah, how could I forget them."
The so-called CRO, the full name is called "Contract Research Organization" in Chinese.
Originated in the United States in the early 1980s.
It is a commercial organization that provides professional services for pharmaceutical companies, medical institutions, and small and medium-sized pharmaceutical and medical device R&D companies mainly through contracts.
There are three types of industrial chains.
From 0- (preclinical candidate compound) discovery.
From-IND (Clinical New Drug Application) validation process.
The human clinical trial stage of INNDDA (New Drug Application).
Simply put, the purpose of CRO is to improve the efficiency of drug development.
You can think of all pharmaceutical companies as e-commerce stores, and CROs are e-commerce platforms.
When it comes to CRO, we have to mention the domestic "Yao Ming Kangde" and "Tiger Medicine".
For example, Yaoming Kangde is the "Ali of the CRO world", and their slogan is - let the world have no difficult medicines and intractable diseases...