Supreme Pharmacist System Chapter 156: Mutation Breeding
Hearing Zhou Wen's words, Zhu Linqing secretly said "bad" in his heart.
Listening to the other party's meaning, it is clear that a CRO company has offered more favorable conditions.
After hanging up the phone, Zhu Linqing looked at the new version of the patented technical description of sildenafil granules on the computer, and couldn't help frowning.
Although Yaoming Kant's conditions are harsh, they are considered "conscience prices" in the industry. Generally, CRO companies can't say that they can offer better conditions than Yaoming Kant's.
Since this CRO company dares to grab food, it must also see the huge market potential of this drug.
Even, sildenafil granules have been made in advance according to the technological process, and preliminary clinical trials have been done, and the efficacy is very significant, so I can't wait to cooperate with Zhou Wen.
After some analysis, Zhu Linqing believes that his guess should be not far from the truth.
Thinking of this, he immediately picked up the phone and called the laboratory.
"Hey, Director Shao, I sent a document to your mailbox. You can follow the above technical process and make it for me as soon as possible. Within 48 hours, I will get the drug efficacy evaluation report."
Two days later...
Zhu Linqing received the drug efficacy test report.
Skip the previous toxicology test data reports and see the results directly.
Number of internal testers: 6.
2 had mild ED, 2 had moderate ED, and 2 had severe ED.
According to the test, the new version of sildenafil granules has a particularly significant effect on the treatment of ED symptoms. The 6 participants in the test all have very eye-catching data...
When Zhu Linqing looked at the test report, her bowels were full of regrets.
With such efficacy, if the side effects are not too obvious when going back to the clinical trial, it is almost a 100% thing to replace the old sildenafil tablets after going back to the market.
"No, I can't just give up..."
Zhu Linqing immediately decided to have a detailed interview with Zhou Wen.
No matter how bad it is, I have to find the company that cut the beard and get a piece of the pie.
…
On the other hand, Xu Yuting came to Jiangzhou City on the afternoon of the 30th.
At three o'clock in the afternoon on December 31, I met Zhou Wen in the office of Hengfeng Building in Jinhu District.
Exception Chen Zhiyuan and lawyers from both sides were also present.
"Hello Mr. Xu~"
"Hehe, hello~"
The two men shook hands while looking at each other up close.
In Zhou Wen's eyes, Xu Shuangyu's little aunt has an excellent demeanor and an elegant temperament, and is different from the so-called strong women. Xu Yuting is full of the personal charm of a female entrepreneur, which makes people very good.
In Xu Yuting's view, Zhou Wen looked much more real than the brilliant young genius on the podium.
"This is Chen Zhiyuan, the general manager of Huanyu."
"Hello, Mr. Chen."
"Hello Mr. Xu, please take a seat."
"Well, okay..."
Xu Yuting is a standard businessman, and Zhou Wen is also considering how to maximize the benefits of patents.
So I didn't have too much politeness. After a few simple greetings, I went straight to the topic.
In fact, Xu Shuangyu had already explained Longkang's conditions in general.
Zhou Wen authorized Longkang to license the new sildenafil granules, and Longkang was responsible for the promotion and operation.
The money you make will be divided into 19%.
Ninety percent of Long Kang and one percent of Zhou Wen.
Don't get excited yet.
Zhou Wen's 10% is 10% of the total sales.
Remember, it's "sales."
In other words, if the new version of sildenafil granules is launched, the annual sales will reach 1 billion, and Zhou Wen will receive 100 million.
10 billion is a billion.
Although Longkang Group has taken 90% of the total, they are responsible for clinical trials, new drug marketing applications, and promotion and sales of the 90%.
Secondly, the profit of downstream dealers is divided into these, and it is also deducted from the 90%, so in fact, the profit obtained by Longkang will be greatly diluted.
In addition, the two sides also have a guarantee agreement.
From the signing of the agreement, regardless of whether sildenafil granules can be marketed or not, and how the sales are after the listing, a patent fee of 20 million yuan (included in sales) must be paid to Zhou Wen every year.
Because of this, Longkang basically made no money in the first three years after deducting all costs. And not making money means losing money.
So Longkang is betting on the late-stage market.
Winning the clubhouse tender model, losing to the sea to work.
Xu Yuting and Zhou Wen negotiated some details of the contract, but the overall direction remains the same.
After half an hour of research and discussion, Chen Zhiyuan, on behalf of Zhou Wen, formally signed an authorization contract with Long Kang.
Zhou Wen's authorized subject is not him, but Huanyu Biotechnology Co., Ltd.
Because he is a technology shareholder, he has already handed over the patent rights to Universal Biotechnology Co., Ltd., and then authorized by Universal to Longkang Group.
After the return of the shares is negotiated again, the patent rights will be changed to the main body of the company.
This can not only improve the intangible assets and corporate image of the company, but also involve applying for government projects, patent funding, and reasonable tax avoidance, etc...
In short, there are many benefits.
"Mr. Xu, it's a pleasure to work with."
"Happy cooperation~ After New Year's Day, the guaranteed patent fee of 20 million will be credited to the account of Universal Company first."
"Well, okay..."
Zhou Wen then sent Xu Yuting downstairs.
At the entrance of the company building, Xu Yuting suddenly smiled and said, "By the way, Pisces will return to China next week."
While speaking, Xu Yuting watched Zhou Wen's expression.
Zhou Wen smiled and said, "Well, she told me to invite her to dinner when she comes back."
Xu Yuting didn't see anything on Zhou Wen's face, she showed a bright smile and said, "Then I'll go first."
"Okay, Mr. Xu, take a slow walk..."
Zhou Wen watched Xu Yuting ride the spinner slowly start, and then disappeared from sight.
He turned upstairs, grabbed some things, and was about to leave.
Chen Zhiyuan came over and laughed and said, "Old Zhou, last time that Xiaomin kept asking me why your phone couldn't get through, you blocked her?"
Zhou Wen said: "No, I just reported a number."
Chen Zhiyuan grinned and said, "Fantastic~ You have already mastered the essence of not taking the initiative, not rejecting, and being irresponsible."
"Fuck off~ it's because of you, I'm so depraved now."
"Don't say that. Everyone has a love for beauty. At most, it is a little bit of fraternity. How can it be called degeneration?"
"Xingxingxing, you continue to go to Fraternity. I'm going to the laboratory~"
Zhou Wen took the car keys and was ready to leave.
Chen Zhiyuan said: "Lend me your car, I'll wait to see a client~ My car is too bad."
"Then give me your car." Zhou Wen threw the key to Chen Zhiyuan.
Chen Zhiyuan spread his hands and said, "I lent my car to someone in the company to do business."
Zhou Wen said speechlessly: "Then what am I driving?"
Chen Zhiyuan laughed and said, "You drive a Ferrari. There are tens of millions of cars, so you can't throw them in the garage to eat ashes every day."
Zhou Wen: "So how can I drive to the laboratory?"
"How about... I'll borrow an electric car for you to drive with Xiao Liu at the front desk?"
"Roll~"
"Ah~ OK." Chen Zhiyuan walked away with the key.
"Let's talk about the bag." Zhou Wen didn't bother to call Didi, so he took the key of the Ferrari F12tdf from the office and went downstairs.
…
No. 404, Jinhu District Industrial Park, Huanyu Institute of Biotechnology.
In the open-plan office, seven or eight people, including Wang Hua, Sun Xin, Song Xuezhang, Bai Xuan, Luo Chunlei, were gathered around to study and discuss.
This is the person in charge selected by many doctors. They are very strong academically and have certain leadership skills.
Everyone agrees.
And the technology they are discussing at this time is "mutagenic breeding", which is one of the key development projects of the world in the next step.
The so-called mutation breeding technology is actually similar to the rice aphid genetic modification technology studied by Zhou Wen before.
Under man-made conditions, using physical, chemical and other factors to induce mutations in organisms, select from them, and cultivate new varieties of animals, plants and microorganisms.
For example, chemical mutagenesis, the more commonly used alkylating agents, such as ethyl methanesulfonate (EMS) and diethyl sulfate (DMS).
The method of use is very simple, dilute it to a certain concentration, and then put the seeds that need to be mutagenized in for a period of time.
Afterwards, the mutagenized seeds are germinated, and plants with the desired phenotype are selected, and then through selfing or hybridization, mutants that can stably inherit are selected.
Of course, the workload of screening is very huge. Take tomato as an example, sometimes tens of thousands of seeds are screened to find the desired traits.
And physical mutagenesis.
The principle is to use various radiations to accelerate the mutation rate of plants, among which Gamma rays, alpha rays, beta rays, gamma rays, X rays, ultraviolet radiation, etc. are commonly used. These operations require special equipment.
One of the more famous ones is the laboratory of the Radiation Breeding Research Institute of Nippon Benzene, which built a tower for radiation treatment, surrounded by a test field.
After some discussion, two research targets were selected - grapes and strawberries.
These are two kinds of fruits commonly found in greenhouses in Sudong Province.
Just when they were about to assign tasks, footsteps came from the door of the conference room, and everyone turned their heads subconsciously to see that it was Zhou Wen.
"Zhou Suo is here."
"Zhou's favorite."
"Hehe, everyone is here, sit and sit..."
Zhou Wen stretched out his hand to signal everyone to sit down, then sat down next to Wang Hua, "What are you discussing?"
While he was talking, he had seen the research plan on the table, as well as related materials about mutagenesis technology.
Song Xuezhang, sitting opposite Zhou Wen, said: "We have just selected two targets..."
Following Song Xuezhang's narration ~IndoMTL.com~ Zhou Wen suddenly heard four or five mission prompts in succession.
Zhou Wen: "..."
He has never received so many tasks at once.
Open the system tasks and take a look, there is a long row of new tasks on the list.
[Mission 1: Radiation Breeding.
Requirements: Establish a grape radiation breeding research group.
Reward: 2000 subject experience, 1000 points, a chance to draw a lottery (Bronze)]
[Task 2: Chemical breeding.
Requirements: Establish a research group for chemical breeding of grapes.
Reward: 2000 subject experience, 1000 points, a chance to draw a lottery (Bronze)]
【Mission 3: Radiation Breeding 2.
Request: Establish a Strawberry Radiation Breeding Research Institute...]
Mission 3 has the same requirements as Mission 4, except that the requirements are changed from grapes to strawberries.
The first few tasks, in his opinion, are the system sending points.
But the latter is more exaggerated.
For example, task 5 requires the cultivation of grapes with an average single grain of 50 grams.
China's largest grape variety, Tengmin grapes, has an average single grain of only 22-30 grams, and the largest is only 35 grams, which has nearly doubled.
Task 6, requires the cultivation of a single strawberry with a maximum size of 500 grams.
This is even more exaggerated, the world record is only 231g, which is more than doubled, the system really looks up to him...
——
ps: I'm sorry, please...