Supreme Pharmacist System Chapter 91: Prions

Zhou Wen then spent 200 points to learn the formula of biological anti-wrinkle cream.

Zhou Wen checked it out, and it was as expected. It was also necessary to purchase a special biological enzyme additive from the system store.

Let's put this aside for now.

After calming down, Zhou Wen thought about it a little and upgraded the pathology to LV2.

Pathology and pharmacology complement each other. From the perspective of pharmacy, only by knowing more about the causes, mechanisms, and developmental laws of human diseases, as well as the morphological structure of the body during the disease process, can we better study drugs.

With the upgrade of [Pathology], a lot of knowledge poured into Zhou Wen's brain.

The pathological knowledge stored in the brain quickly becomes alive.

I used to know only one, but I don't know the other, but now I have a deeper understanding.

Combined with pharmacology, he's really become a brilliant doctor now.

And a general practitioner.

He understands the causes and treatment options for most routine diseases.

Such as inflammation, cardiovascular disease, respiratory disease, digestive system disease, lymphatic hematopoietic system disease, immune disease, urinary system disease, etc.

Zhou Wen was so excited that he almost jumped up.

It may be difficult for outsiders to understand his current mood.

Just like a scumbag who knows the content of the college entrance examination in advance, then memorizes all the knowledge points and the answers to the questions in advance, and waits for life to counterattack. What does it feel like?

It's so refreshing. Is there any wood?

And Zhou Wen "memorized" not only the answers of the college entrance examination, he even "memorized" the answers of the college entrance examination.

This feeling of taking shortcuts in life made Zhou Wen's 360 pores open.

He now wants to find someone to see a doctor, such as orthopedics...

Sunday morning.

Maybe it was because of the rain yesterday. The weather was exceptionally good today. The fiery sun rose from the sky early, scorching the earth, and the air gradually began to heat up.

At eight in the morning, Zhou Wen took the bus to Tianhai Intellectual Property Agency Co., Ltd. on Jianghai Road.

Meet the general manager Meng Xiang in the office.

Meng Xiang is very young, only in his early 30s. He is wearing a red striped shirt + black trousers, and a pair of gold-rimmed glasses on the bridge of his nose. He has a refined temperament and looks like a Kochi.

"Hello Mr. Zhou~"

"Hello Manager Meng."

The two had a brief chat and then took their seats.

Zhou Wen took out the printed patent application specification from his computer bag, "Manager Meng, take a look."

"Okay." Meng Xiang took the thick stack of instructions, pushed the frame on the bridge of his nose with his middle finger, and turned to the first page to read.

Meng Xiang watched quickly, with ten lines at a glance.

Like those process flow diagrams, formulas, etc., skip it directly.

Thirty-five thousand words, plus picture formulas, etc., totaling nearly 30 pages, Meng Xiang saw the end in five minutes.

Those things will naturally be reviewed one by one. What he needs to know is, what is the result of such a long patent specification?

Where the **** is it?

"Product effect description: After refining and improving this process, the effect of the powerful version of sildenafil tablets will be increased by 200%~300% on the original basis."

Meng Xiang: "..."

Meng Xiang felt extremely speechless.

He doesn't know what to say.

Seeing the face of the classmate who is the chairman's precious daughter, he rushed to the company on Sunday to wait for the other party for more than an hour, but what he waited for was the prescription of this Arabian Nights...the process.

What international joke?

Who do you think you are, and improve sildenafil?

Since the early 1990s by Pfizer Pharmaceuticals in the United States, after discovering the effect of sildenafil in the treatment of ED, hundreds of pharmaceutical engineers have invested in research and development.

The technological process has already undergone many trials and tribulations.

You casually say that you have improved other people's technological processes, and the effect has increased by 200%~300%.

Are you looking down on yourself too much, or do you look down on Pfizer's pharmaceutical engineers too much?

"Cough cough~" Meng Xiang coughed and said, "That, Mr. Zhou... I don't think it is necessary to apply for this patent."

Zhou Wen wondered: "Why?"

Meng Xiang stretched out his hand and pushed down the frame, and said euphemistically, "I don't think it's possible to patent this process.

You need to know that it took Pfizer nearly 10 years to develop sildenafil, and the post-marketing process has undergone continuous improvement for 20 years, so it is not easy to surpass them. "

Zhou Wen smiled.

Without clinical trial results, anyone who sees this patent application specification will think it is a fantasy.

He didn't argue, but smiled and said, "Mr. Meng said yes, but I still want to register a patent."

Meng Xiang knew that a person who could write a 35,000-word patent application specification would not be able to get rid of the idea of ​​registering a patent with just a few words, so he did not try to persuade him.

"Since you insist, then do as you say."

Zhou Wen asked: "What about the cost?"

Meng Xiang thought for a moment and said, "To be honest, if you calculate the value in your patent specification, the agency fee is very expensive, but you...

Well, add all the costs together, and you can give a total of 150,000. "

"150,000... It's still a friendship price. These top agencies are really expensive."

Zhou Wen said something to himself, and asked, "Do you think this will work? I'll pay 10,000 first, and then give the rest after a while?"

Meng Xiang nodded, "Yes."

Then the two sides signed an agency agreement, and Zhou Wen gave Meng Xiang a copy of his ID card.

After that, Alipay transferred 10,000 yuan to Tianhai's company account.

Even if the agency is done.

The rest will be handled by Tianhai Office. He just needs to wait for the patent certificate.

Zhou Wen got up to leave.

Meng Xiang kept bringing him to the elevator entrance, and then turned back to the office after watching the elevator go down.

On the way, I picked up the phone and dialed.

"Hey, miss, it's already done...he has this patent...a total of 150,000..."

As soon as Meng Xiang said the price, a roar suddenly came from the phone, "What, 150,000, so much?"

Meng Xiang smiled bitterly: "This price is already very cheap. If calculated according to the market price, at least 1 million agency fees."

"Don't be so dark-hearted, okay? How can he have so much money? And you said that it's impossible to succeed, so why bother with other people's money... just 10,000 yuan."

"I didn't cheat him for money... and I have already signed a contract, so it's hard to change it."

"Then I don't care, you can do it yourself."

"I...dududu..." As soon as Meng Xiang was about to speak, the phone was hung up.

Meng Xiang looked at the phone that hung up, and said depressedly, "Girls' elbows are turned out, it's true~IndoMTL.com~ You must never give birth to daughters in the future."

…

As soon as Zhou Wen arrived downstairs, he received a call from Yang Liqun, asking him to come to the testing center.

Zhou Wen hurried to the testing center.

Yang Liqun handed over an electrophoresis test report, "Look at it."

"What's the matter?" Zhou Wen took a look and found that it was a very rare "prion".

The knowledge of prions quickly emerged in Zhou Wen's brain.

Strictly speaking, "prion" is not a virus, it is a toxic biomolecule that contains only protein and no "nucleic acid", so it is also called "prion protein".

Prion is currently recognized as a misfolded protein in the world, and its three-dimensional structure has not yet been recognized.

As a self-replicating peptide chain, the prion protein may be a more ancient and primitive biomolecule than the nucleic acid chain.

It may have been an accidental "amino acid combination" that gave it the original characteristics of life such as "replication".

However, although it is not a virus, prions are no less terrible than viruses, or even worse.

The famous "mad cow disease" (CJD) is caused by prions.

A variety of neurological diseases, such as "Alzheimer's disease" and "Parkinson's disease", are inextricably linked with prions.

The clinical manifestations of these diseases are generally central nervous system diseases such as ataxia, tremor (hand tremors), postural instability, dementia, hypersensitivity and abnormal behavior.

Yang Liqun said: "The clinical manifestations of this case are very special. He would often laugh uncontrollably..."

——

ps: I'm sorry, please...